Aliness Folian 800 μg, 60 capsules

• Folate for pregnant women 800 µg
• 60 capsules
• does not contain any additional substances
• without gluten, lactose, soy

FOLIAN for pregnant women 800  by ALINESS is a rich source of highly bioavailable folate in the patented Quaterfolic® form.

The term "Folic acid" includes all forms of folates. If the word "folate" sounds like "leaves" to you in English, it's no accident. The words share a common root (the Latin word folium, meaning "leaf"), which helps remind us that green plant foods can be one of the richest sources of folate.

Folates are susceptible to oxidation, rapidly lose activity in food and are largely, up to 90%, destroyed by cooking.

ACTION OF FOLATES:

• contribute to the growth of maternal tissues during pregnancy
• reduce the risk of developing neural tube defects in the developing fetus
• help in proper blood production
• help maintain proper homocysteine ​​metabolism
• help maintain proper psychological functions
• contribute to reducing the feeling of fatigue and weariness
• help in the proper functioning of the immune system
• they take part in the process of cell division
• help in the proper synthesis of amino acids

Synthetic folic acid

Folic acid obtained from food must be metabolized to 5-methyltetrahydrofolate (5-MTHF) to achieve full metabolic effectiveness.

Most of our folate intake comes from synthetic versions of folic acid in supplements and added to foods. Today we know that folic acid undergoes complex metabolism and that there are differences among populations in the ability to effectively metabolize folic acid into its bioactive form (1,2).

Folate in food is hydrolyzed to monoglutamate in the intestine before being absorbed by active transport through the intestinal mucosa. Therefore, before entering the bloodstream, the monoglutamate form is reduced to tetrahydrofolate (THF) and converted to methyl forms.

Folic acid, on the other hand, is first reduced to dihydrofolate by the enzyme dehydrofolate reductase (DHFR) and then to tetrahydrofolate. In humans, the intestine appears to have a very high capacity to convert reduced folate from food into 5-MTHF, but a limited capacity to reduce folate.  In fact, it reaches the liver in an unmetabolized form.

Quatrefolic®, a highly bioavailable form of folate, may be the best choice when it comes to supplementing active folate to support and regulate the methylation cycle. (7,8).

Quaterfolic®  - SOURCE OF BIOAVAILABLE FOLATE, IN THE FORM OF ACTIVE FOLATE

Quatrefolic®  crosses the gastric barrier and is absorbed mainly in the small intestine by a carrier mechanism.

The biotransformation of folic acid to 5-MTHF in the liver is regulated by two polymorphic enzymes,  DHFR and MTHFR. DHFR enzyme activity appears to be low and highly variable. Chronic exposure of the liver to folic acid may induce saturation with this nutrient, which may result in systemic circulation of unmetabolized folic acid. Additionally, some people have genetic changes that lower DHFR activity.

A new study published in 2014 clearly indicated that 86% of folate in the hepatic portal vein is unmetabolized, with almost all of natural folate being converted properly. (3),(4).

Quaterfolic®  BIOAVAILABILITY

The oral bioavailability of an active ingredient is highly dependent on its solubility. The compound is absorbed after dispersion and dissolution in the fluid in the intestines.

What does solubility mean?

The high solubility in water means that Quatrefolic® can be better absorbed by the mucosal cells, which facilitate access to the blood and circulation.

The high water solubility means that Quatrefolic® can be easily absorbed by mucosal cells, which facilitate access to the blood and circulation, with the potential to improve the bioavailability of this chemical form of folate.

The exceptionally high solubility of Quatrefolic® in water is due to two specific features of the ingredient: the glucosamine-forming agent and the amorphous chemical structure of the product

The amorphous state provides inherent solubility, guaranteeing a uniform and reproducible dissolution process, while the crystalline alternative cannot provide this.

Quaterfolic®  STABILITY

Quatrefolic® exhibits extraordinary long-term chemical stability guaranteeing completely unchanged purity even after several months, and an analysis reduction over 18 months of less than 1%, which allows for easy use and storage.  The pH value of Quatrefolic after dissolution is neutral. This value also provides higher stability to the molecule, protecting it from hydrolytic degradation.

The stability of Quatrefolic® in powder form was tested in accordance with ICH guidelines (International Council for Harmonization of Technical Requirements for the Registration of Medicinal Products for Human Use) both at room temperature and other conditions of storing samples in airtight containers protected from light, and with measurement of purity and result at different points.

Medicaline has deliberately chosen to conduct Quatrefolic® stability studies in accordance with the strictest guidelines specifically required for pharmaceutical ingredients, ensuring independent and reliable criteria in order to make a claim about long-term chemical stability before promoting the product to its customers.

The freeze-dried ingredient can be used without specific or restrictive conditions, can be easily combined with other ingredients and excipients, and can be stored at room temperature instead of at 2-8°C like other folate derivatives.

RECOMMENDED CONSUMPTION

Due to the fact that Quatrefolic® contains a metabolically reduced form of folate, used and stored in the human body, it is completely bioavailable.

The recommended dose for pregnant women is 800 μg of pure folate. Based on: Nutrition standards for the Polish population - amendment edited by prof. Ph.D. med. Mirosław Jarosz, Institute of Food and Nutrition 2012.

Quaterfolic® Impact on health and function

In 2014, the European Commission approved the use of Quatrefolic® in the European Union as a New Food Ingredient. In 2015, Annex II to Directive 2002/46/EC was officially amended to include Quatrefolic®, which can be used in the production of dietary supplements sold in the European Community.

The effect of folates on our health, assessed by the European Food Agency (EFSA) and approved by the European Commission, is described in the Annex to Commission Regulation No. 432/2012 of 16 May 2012 establishing a list of permitted health claims regarding food, other than claims relating to to reduce the risk of disease and the development and health of children. Pursuant to this Regulation, folates:

• help in proper blood production
• help maintain proper homocysteine ​​metabolism
• help maintain proper psychological functions
• contribute to reducing the feeling of fatigue and weariness
• help in the proper functioning of the immune system
• they take part in the process of cell division
• help in the proper synthesis of amino acids
• contribute to the growth of maternal tissues during pregnancy

Folate supplementation is recommended during pregnancy and lactation, for infants and small children, as well as the elderly.

PREGNANCY/LACTATION

An increased need for folate occurs during very active growth of the body's cells, such as during pregnancy and lactation.

Quatrefolic® as a source of (6S)-5-methyltetrahydrofolate (5-MTHF) may be particularly useful in providing a nutritionally active form of folate in the period before conception, during pregnancy and lactation.

Folate concentrations in breast milk are maintained at the expense of folate reserves in the mother's body.

A breastfeeding woman needs 128 μg of additional folate per day to replenish folate consumption.

5-MTHF has been shown to be effective and perhaps more effective than folic acid in maintaining erythrocyte folate concentrations during lactation.

Babies and children:

Folate is a critical nutrient when cell growth in the body is very active. It helps in the proper functioning of the immune system.

Adults:

Folate is involved in the production of key neurotransmitters in the brain, helping to maintain proper psychological functions.

Folate is a cofactor in many important biological reactions, and its deficiency can occur at all stages of life. Folate supplementation may improve the quality of life by reducing the feeling of fatigue and weariness

Elder people:

Folate deficiency occurs in approximately 30% of the elderly population.

Folate supplementation is important in older people because with age the level of homocysteine ​​in the blood increases and its metabolism depends on folate.

As part of the aging process, numerous physical and physiological changes occur.

Aging is associated with changes in the functioning of the gastrointestinal tract, which may possibly affect the absorption of various forms of folate. Supplementing folate with high bioavailability, especially in this age group, helps support proper psychological functions such as concentration, memory and learning.

*RWS: daily reference intake for adults. Reference intake for an average adult (8400kJ /  2000 kcal)

Ingredients:  bulking agent: microcrystalline cellulose, glucosamine salt of (6S)-5-methyltetrahydrofolic acid Quatrefolic®.

Recommended daily dose necessary to obtain the beneficial effect of the product:  1 tablet daily, during a meal. Do not exceed recommended servings for consumption during the day.

The product is dedicated to pregnant women. Use in pregnant women after consulting a doctor . The product cannot be used as a substitute for a varied diet. It is recommended to follow a varied diet and a healthy lifestyle.

Storage conditions:  Store at room temperature out of the reach of small children. Protect from moisture.